creb inhibitor — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T5318	666-15	CREB inhibitor	Epigenetic Reader Domain
	666-15 (CREB inhibitor) is a potent and selective CREB inhibitor (IC50: 81 nM).		Epigenetic Reader Domain
T8890	653-47 hydrochloride		Epigenetic Reader Domain
	653-47 hydrochloride is a potentiator, significantly potentiates the cAMP-response element binding protein (CREB) inhibitory activity of 666-15. It is also a very weak CREB inhibitor with IC50 of 26.3 μM.		Epigenetic Reader Domain
T7856	Naphthol AS-E	nAS-E	Epigenetic Reader Domain , Histone Acetyltransferase
	Naphthol AS-E (nAS-E) is an the KIX-KID interaction and CREB-mediated gene transcription inhibitor.		Epigenetic Reader Domain , Histone Acetyltransferase
T24212	XX-650-23	XX65023,XX 650 23	Apoptosis , Epigenetic Reader Domain
	XX-650-23 is a small molecule CREB inhibitor that blocks the critical interaction between CREB and its required coactivator, CBP (CREB-binding protein), inducing apoptosis and cell cycle arrest in AML cells, and can be u...		Apoptosis , Epigenetic Reader Domain
T15216	EML 425		Epigenetic Reader Domain , Histone Acetyltransferase
	EML 425 is a potent and selective inhibitor of CREB binding protein (CBP)/p300 (IC50s: 2.9 and 1.1 μM, respectively).		Epigenetic Reader Domain , Histone Acetyltransferase
T8774	MS7972		Epigenetic Reader Domain
	MS7972 is CREBBP inhibitor that blocks human p53 and CREB binding protein association. MS7972 can almost completely block this BRD interaction at 50 μM		Epigenetic Reader Domain
T3973	PF-CBP1		Epigenetic Reader Domain
	PF-CBP1 HCl is a highly selective inhibitor of the bromodomain of CREB-binding protein(CREBBP). It inhibits CREBBP (IC50: 125 nM) and p300 bromodomains (IC50: 363 nM).		Epigenetic Reader Domain
T7297	KG-501	Naphthol AS-E phosphate	Epigenetic Reader Domain
	KG-501 (Naphthol AS-E phosphate) is a cAMP response element-binding protein (CREB) inhibitor(IC50 : 6.89 μM).		Epigenetic Reader Domain
T1516	Curcumin	Diferuloylmethane,Natural Yellow 3,Indian Saffron,Turmeric yellow	Mitophagy , Epigenetic Reader Domain , Ferroptosis , Influenza Virus , Nrf2 , Histone Acetyltransferase , HDAC , Autophagy
	Curcumin (Natural Yellow 3) is a phenolic natural product, an inhibitor of histone acetyltransferase p300/CREB (IC50=25 μM) with specificity. Curcumin has a wide range of pharmacological activities such as antitumor, ant...
T3217	PF-CBP1 hydrochloride	PF-CBP1 HCl	Epigenetic Reader Domain , Histone Acetyltransferase
	PF-CBP1 hydrochloride (PF-CBP1 HCl) is a highly selective inhibitor of the bromodomain of CREB-binding protein(CREBBP).It inhibits CREBBP and p300 bromodomains with IC50 of 125 and 363 nM respectively.		Epigenetic Reader Domain , Histone Acetyltransferase
T27083	Crebinostat		Epigenetic Reader Domain , Histone Acetyltransferase , HDAC
	Crebinostat is a potent histone deacetylase (HDAC) inhibitor, inhibiting HDAC1, HDAC2, HDAC3, and HDAC6 with IC50s of 0.7 nM, 1.0 nM, 2.0 nM, and 9.3 nM, respectively.Crebinostat increases the density of synapsin-1 punct...		Epigenetic Reader Domain , Histone Acetyltransferase , HDAC
T28867	STF-038533
	STF-038533 is an inhibitor of CREB target gene transcription.
T70736	NSC-45576
	NSC-45576 is an inhibitor of CREB-CRE interaction.
T64247	CREB-IN-1 TFA
	CREB-IN-1 TFA is a potent, orally active CREB inhibitor with an IC50 value of 0.18 μM. CREB-IN-1 TFA exhibits inhibitory effects on the growth of breast cancer cells.
T24501	MS2126	NSC 71584,NSC71584,MS 2126,MS-2126,NSC-71584
	MS2126 is a Human p53 and CREB Binding Protein interaction inhibitor.
T61314	DC-CPin7
	DC-CPin7, a powerful inhibitor of the bromodomain of CREB-binding protein (CBP), exhibits an IC50 value of 2.5 μM [1].
T21131	NASTRp	Naphthol AS-TR phosphate
	NASTRp, an inhibitor of CREB-CBP complex, possesses anti-cancer effects along with cell cycle regulation, autophagy suppression, and endoplasmic reticulum stress.
T24606	PDE7 inhibitor S14	PDE7 inhibitor-S14,S14
	PDE7 inhibitor S14 is a cell-permeable PDE7 inhibitor that acts by targeting the cyclic adenosine monophosphate (cAMP)/cAMP-response element-binding protein (CREB) pathway.
T63041	DS01080522
	DS01080522 is an inhibitor of PRKACA. DS01080522 inhibited PRKACA kinase activity (IC50.0.8 nM) and CREB phosphorylation (IC50.66 nM). DS0108052 can be used to study cancer.
T61719	DC-CPin711
	DC-CPin711, a potent and selective inhibitor of the bromodomain of CREB-binding protein (CBP) with an IC50 of 0.0626 μM, effectively halts the cell cycle at the G1 phase and promotes apoptosis [1].